EFFECT OF PREHOSPITAL SYSTEMIC THROMBOLYSIS ON LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN ST-SEGMENT ELEVATION ACUTE MYOCARDIAL INFARCTION

A.l. Alavi, S.r. Kenzhaev, I.i. Kakharov

Abstract

https://doi.org/10.54185/TBEM/vol14_iss3/a4

Objective: to study the effect of prehospital thrombolysis on left ventricular systolic dysfunction in patients
with acute ST-segment elevation coronary syndrome.
Material and methods: The study included 70 patients with acute coronary syndrome with ST-segment
elevation. Patients were randomized into two groups: control (group A) - 35 patients receiving standard
therapy, and hospital TLT. Group B included 35 patients who underwent standard therapy and prehospital
TLT. All 70 patients underwent echocardiography 1 day after myocardial revascularization and 3 months
later.
Results: the use of early myocardial reperfusion in patients with STEMI had a positive effect on central
hemodynamics, reduced the development of LV volume overload, as a result of which end-diastolic and
systolic volumes did not change during 3 months of follow-up. LVEF grew in both groups, and its growth
was more pronounced in group B.
Conclusion: timely prehospital reperfusion reduces the severity of myocardial damage and thus prevents
the development of severe systolic myocardial dysfunction LV.