Дестабилизация ишемической болезни сердца у больных с тревожно-депрессивным синдромом

Э.Н. Ташкенбаева, З.А. Насырова, Г.Б. Нуралиева, А.Х. Бурибаева, Н.Т. Умарова

Abstract

Aim. To study the relationship between anxiety-depressive disorder and immune-inflammatory response
in patients with unstable angina pectoris.
Material and methods. The study included 117 patients, women – 72 (62.1%), men – 45 (37.9%). The age
of the patients was from 31 to 88 years old, the average age was 62.3±11.37 years. Arterial hypertension
was observed in 98 (83.8%) patients, type 2 diabetes mellitus – in 56 (47.8%), 43 (36.7%) of the examined
patients had previously suffered myocardial infarction.
Results. In patients with unstable angina (UA) pectoris in comorbidity with anxiety-depressive syndrome,
the indices of low-density lipoproteins and total cholesterol were higher by 19.5% and 38.2%, respectively.
Indicators of low-density lipoproteins were 12.1% below the control level, which indicates a violation of
lipid metabolism in patients with unstable angina pectoris (UA) in comorbidity with anxiety-depressive
syndrome.
Conclusion. Based on analyzes of pro-inflammatory and anti-inflammatory factors, it is possible to predict
the progression of coronary artery disease, features of the clinical course of ischemic heart dysfunction,
which will make it possible to carry out the necessary scientifically grounded preventive measures, as well
as postpone the time of manifestation of disease progression and the development of severe cardiovascular
complications as much as possible.