RESEARCH OF THE EFFECT OF A NEW ANTIHYPOXANT AND ANTIOXIDANT AGENT IN EXPERIMENTAL HYPOXIA CAUSED BY ACUTE BLOOD LOSS

Zh.J. Khuzhakhmedov, L.I. Shevchenko, H.Y. Karimov, T.R. Alimov, R.K. Rakhmanberdieva

Abstract

Aim. To study the antihypoxic and antioxidant effect of the new blood substitute «Rheoambrasol» in acute
blood loss.
Material and methods. The experiments were carried out on 60 rats, in which the experimental model of
acute blood loss was reproduced. The effectiveness of using the new blood substitute «Rheoambrasol” in
acute blood loss was determined in comparison with the drug “Rheopolyglyukin”.
Results. The results obtained, it can be seen that blood loss is accompanied by hypoxia, as evidenced by the
concentration of hypoxia-inducible factor (HIF-1α), which increased in the second group by 4.1 times. After
the infusion of “Rheoambrasol”, the content of hypoxia-inducible factor HIF-1α in blood plasma decreased
2.9 times, compared with the value after blood loss, which was 44.4% lower than after the infusion of the
drug “Rheopolyglucin”. After the use of the drug “Rheoambrasol”, the balance of lipid peroxidation activity/
antioxidant system activity (LPO/AOS) in the blood, myocardium and liver was restored.