RELATIONSHIP BETWEEN CLINICAL COURSE OF ISCHEMIC STROKE AND POLYMORPHISM OF PLASMINOGEN ACTIVATOR INHIBITOR (PAI) GENE

S.R. MUBARAKOV, K.T. BOBOEV

Abstract

Objective. Evaluation of importance of 675 4G/5G polymorphism of PAI-1 gene in pathogenesis of ischemic stroke (IS).Material and methods. 37 patients with IS admitted to the Republican Research Centre of Emergency Medicine were investigated. 68 nonrelative healthy patients of Uzbek population without anythrombose-associated diseases composed control group. Results. The incidence of mutant 4G-gene in the main and control groups was 55.4% and 30.0% respectively. Odd ratio showed that the presence of 4G allele in 675 position of PAI gene increases the risk of thrombosis 2.2 times (χ 2=7.3; P=0.007; OR=2.2; 95% CI 1.239-3.927).Conclusion. 675 4G/5G polymorphism of PAI-1 gene has important role in pathogenesis of IS and its clinical course.