Application of artificial coatings with silver particles in thermal burns of the skin in experiment

V.U. Ubaydullaeva, U.R. Kamilov, A.Zh. Fayazov, Kh.E. Yunusov

Abstract

Described morphological changes in thermal lesions of the skin in animals with burns II-IIIAB degree,
using in the treatment of a polymer film containing silver nanoparticles at a concentration of 0.00216%,
0.00324%, 0.00432%, 0.00648%, based on experimental data. The object of the study was 60 white rats,
divided into 4 groups. Studies of the central and peripheral parts of the burn zone were carried out on the
7th, 15th and 30th days with a comparison of the clinical and morphological results obtained. At the same
time, the best results were noted in 1 (0.00216%) and 4 (0.00648%) groups, since it was in these groups
that connective tissue was formed by the 30th day, while in 2 (0.00324%) and in 3 (0.00432%) groups,
granulation tissue was formed in the same time intervals. It has been morphologically proven that the
use of Ag-CMC coatings makes it possible to shorten the recovery process, being the most physiologically
acceptable coatings of the wound surface.