Effect of sodium cyclamate in the development of hyperglycemia and insulin resistance

Abstract

Purpose: Studying the effect of the daily acceptable dose of sodium cyclamate, a sweet flavoring substance, on carbohydrate metabolism in rats under experimental conditions.
Materials and methods: 10 mg/kg of sodium cyclamate was dissolved in distilled water and
administered orally to 20 white male experimental rats weighing 160–180 g. The amounts of
glucose, insulin, total protein, albumin, ALT, AST, uric acid, creatinine, cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), Na, Ca, K trace elements
were determined in the blood serum of experimental animals. HOMA-IR and IRI indicators
representing insulin resistance were calculated.
Results. Hyperglycemia was observed in experimental animals under the chronic effect of
sodium cyclamate. At the end of the experiment, the amount of glucose in the blood serum of
the animals increased by 68.4%, and the amount of glycated hemoglobin by 76.0% compared
to the initial index. At day 30, these increases were statistically significant (P>0.05). On the
60th day of the experiment, the amount of insulin increased by 66.4% (P>0.001), HOMA-IR
index and IRI (insulin resistance index) increased by 2.8 times (P>0.001) than initially.