RELATIONSHIP OF TGF-Β1 AND MTHFR GENE POLYMORPHISM WITH THE DEVELOPMENT OF VARICOSE DISEASE AND ITS THROMBOTIC COMPLICATIONS

Abstract

Aim. Identification the association of TGF-β1 and MTHFR genes with the development of lower extremity
varicose disease and its thrombotic complications.
Material and methods. 161 patients with varicose disease (main group) were examined: 111 patients
without thrombotic complications, 50 with phlebothrombosis. The control group included 155 conditionally healthy individuals. We studied the frequency of carriage of the G/G, G/C, C/C genotypes of the
rs1800471 polymorphism in the TGF-β1 gene and the C/C, C/T, T/T genotypes of the rs1801133 polymorphism in the MTHFR gene.
Results. Among patients with venous thrombosis, the frequency of carriage of the heterozygous G/C genotype TGF-β1 gene and the mutant homozygous T/T genotype MTHFR gene was almost 4 times higher
than in control group (χ2
>3,84; p<0,05; OR=3,9; 95% CI:1,64–8,98 and χ2
>3,84; p<0,05; OR=3,1; 95%CI:
1,11–8,49, respectively).
Conclusions. The presence of the heterozygous G/C genotype of the TGF-β1 gene and the homozygous
T/T genotype of the MTHFR gene has diagnostic and prognostic significance and greatly increases the risk
of developing varicose disease and phlebothrombosis.