Functional state of tubular system of kidney in patients with chronic pyelonephritis in period of remission

C.М. Khabibullayev, H.Kh. Mukhamedova, N.T. Mirakbarova

Abstract

Goal. Detection changes of functional state of tubular system of the kidneys in patients with chronic
pyelonephritis.
Patient and methods. The study involved 24 patients with chronic pyelonephritis in remission period.
Patients’ age is 25–69 years (average age 42 years) The control group is consisted of 32 individuals,
without any chronic diseases of internal organs. We studied the activity of enzymes: GOT, GPT, GGT,
alkaline phosphatase, as well as the amount of albumin, glycosoaminoglycan in urine in patients with
chronic pyelonephritis. We carried out clinical, biochemical research methods.
Results. It was revealed: an increase in the activity of the studied enzymes (glutamic oxaloacetic
transaminase (GOT) and serum glutamic pyruvic transaminase (GPT), alkaline phosphatase (ALP),
gamma-glutamine transferase (GTT)) approximately 1.5 times in patients with chronic pyelonephritis.
The amount of albumin, glycosoaminglycan in the urine increased 1.5-2.0 times