INTEGRAL EVALUATION OF THE EFFECTIVENESS OF COMPLEX AND ARTIFICIAL EXTRACORPOREAL LIVER SUPPORT METHODS IN ACUTE LIVER FAILURE

F.G. NAZIROV, R.A. IBADOV, E.L. ISMAILOV, S.KH. IBRAGIMOV

Abstract

The article presents comparative results of intensive care with a complex extracorporeal liver support for acute liver failure of various origins, in terms of assessing the severity of patients condition, according to the most informative scoring systems (APACHE II, SOFA, Glasgow Scoring System, MELD). The study included 117 patients. Integral assessment of acute liver failure severity showed the high efficiency of extracorporeal support. There was more significant decrease in performance by 10th days of intensive therapy on APACHE II scales to 6.4±0.6 points (p<0.05), SOFA – up to 2.7±0.2 points (p<0.05), MELD – up to 16.7±0.4 points (p<0.05) with an improvement in the state of consciousness on the Glasgow Scoring System to 13.3±0.4. Subsequently, there was also a tendency to improve these indicators with more pronounced dynamics in the main group.