Correction of mild craniocerebral injury disorders with curcumin and glycine in experimental animals with varying levels of activity

F.G. Haydarov, D.M.Hashirbaeva, N.V. Voronina

Abstract

The aim of the research is to study the effect of the phytopreparation curcumin, the synthetic preparation
glycine and the curcumin-glycine complex on the organism of animals with mild traumatic brain injury.
Material and methods. Preclinical tests of curcumin, glycine and their complex on 90 laboratory white
outbred male rats weighing 210 ± 4.8 g, which are kept under standard conditions at the Central Scientific
Research Laboratory of the Tashkent Pharmaceutical Institute. Curcumin, glycine and their administration
at a dose of 75 mg / kg, then, after the reproduction of the model of mild brain injury in animals, the balance (system) was assessed using the «walk on a raised bar» test (walking on a raised bar).
Results. The introduction of the curcumin + glycine complex had a more beneficial effect than monotherapy with curcumin and glycine, both on the levels of physical activity and on psychoemotional status.
Conclusion. Analysis of the therapeutic effect of curcumin, glycine and curcumin + glycine complex on
experimental models showed that the most effective and rational for the correction of functional disorders
in behavior is the use of the curcumin + glycine complex.